Heath L, Fox A, McClure J, Diem K, van ’t Wout AB, Zhao H, Park DR, Schouten JT, Twigg HL, Corey L, Mullins JI, Mittler JE (2009). Evidence for limited genetic compartmentalization of HIV-1 between lung and blood. PloS one, 4(9), e6949. (pubmed) (doi)
HIV-1 is frequently detected in the lungs of infected individuals and is likely important in the development of pulmonary opportunistic infections. The unique environment of the lung, rich in alveolar macrophages and with specialized local immune responses, may contribute to differential evolution or selection of HIV-1.