Mullins Molecular Retrovirology Lab

  • Department of Microbiology
  • School of Medicine
  • University of Washington
University of Washington/Fred Hutch Center for AIDS Research

Mullins Lab

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The Mullins laboratory is located in Building F on the South Lake Union campus of the University of Washington School of Medicine. Our lab uses molecular, computational, and virus biology techniques to provide insights into the relationship between HIV and its human hosts in an effort to fight the AIDS pandemic. We use a variety of methods to document and understand the implications of HIV's extraordinary genetic diversity on the immunopathogenesis of AIDS, with a particular emphasis on acute/early infection and superinfection. We then apply this information to develop more effective vaccines and therapies in collaboration with other investigators. Our research work focuses on the acquisition and computational characterization of HIV nucleotide sequences, the development of web tools for related computational studies, in vitro studies of the growth properties of viral isolates, host genetic polymorphism analysis, and high-throughput analysis of cellular transcription.

Lab News

Viroverse now available as open source software

Viroverse is a web application supporting the collection, storage, retrieval, and analysis of our experimental data. We’ve been developing it in our lab for over a decade. At long last, we have made the source code available on GitHub. If you give it a try or want additional support setting up Viroverse in your lab, please let us know.

Recent Publications

Raugi DN, Ba S, Cisse O, Diallo K, Tamba IT, Ndour C, Badiane NMD, Fortes L, Diallo MB, Faye D, Smith RA, Sall F, Toure M, Sall EI, Diallo Agne H, Faye K, Diatta JP, Sy MP, Chang M, Diaw B, Sambou J, Bakhoum R, Sy MD, Niang A, Malomar JJ, Coombs RW, Hawes SE, Ndoye I, Kiviat NB, Sow PS, Seydi M, Gottlieb GS, University of Washington–Senegal HIV-2 Study Group (2021). Long-term Experience and Outcomes of Programmatic Antiretroviral Therapy for Human Immunodeficiency Virus Type 2 Infection in Senegal, West Africa. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 72(3), 369-378. (pubmed) (doi)

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Santiago JC, Goldman JD, Zhao H, Pankow AP, Okuku F, Schmitt MW, Chen LH, Hill CA, Casper C, Phipps WT, Mullins JI (2021). Intra-host changes in Kaposi sarcoma-associated herpesvirus genomes in Ugandan adults with Kaposi sarcoma. PLoS pathogens, 17(1), e1008594. (pubmed) (doi)

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Hemelaar J, Elangovan R, Yun J, Dickson-Tetteh L, Kirtley S, Gouws-Williams E, Ghys PD, WHO-UNAIDS Network for HIV Isolation and Characterisation (2020). Global and regional epidemiology of HIV-1 recombinants in 1990-2015: a systematic review and global survey. The lancet. HIV, 7(11), e772-e781. (pubmed) (doi)

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Aamer HA, McClure J, Ko D, Maenza J, Collier AC, Coombs RW, Mullins JI, Frenkel LM (2020). Cells producing residual viremia during antiretroviral treatment appear to contribute to rebound viremia following interruption of treatment. PLoS pathogens, 16(8), e1008791. (pubmed) (doi)

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Trebelcock WL, Lama JR, Duerr A, Sanchez H, Cabello R, Gilada T, Segura P, Reisner SL, Mayer KH, Mullins J, Bender Ignacio RA (2019). HIV pretreatment drug resistance among cisgender MSM and transgender women from Lima, Peru. Journal of the International AIDS Society, 22(11), e25411. (pubmed) (doi)

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