Ruy M. Ribeiro and Alan Perelson

Recently, a new technique was developed, involving deuterium enriched glucose, that allows the in vivo measurement of the turnover of cells. We will present data from a study which measured the CD4⁺ and CD8⁺ T cell turnover in three different groups: healthy individuals, HIV infected patients and subjects undergoing highly active antiretroviral therapy. We have used simple dynamical models to analyse these data. These models for the labeling and unlabeling of DNA strands during replication of the cell give estimates for the proliferation and death rates of T cells. This presentation will focus on work in progress and the latest results will be discussed.