The Mullins laboratory is located in the Rosen Building on the South Lake Union campus of the University of Washington School of Medicine. Our lab uses molecular, computational, and virus biology techniques to provide insights into the relationship between HIV and its human hosts in an effort to fight the AIDS pandemic. We use a variety of methods to document and understand the implications of HIV's extraordinary genetic diversity on the immunopathogenesis of AIDS, with a particular emphasis on acute/early infection and superinfection. We then apply this information to develop more effective vaccines and therapies in collaboration with other investigators. Our research work focuses on the acquisition and computational characterization of HIV nucleotide sequences, the development of web tools for related computational studies, in vitro studies of the growth properties of viral isolates, host genetic polymorphism analysis, and high-throughput analysis of cellular transcription.
Step Trial Analysis Featured in UW Today
Microm 496D and Microm 499B, Spring Quarter 2011
2012 CTL Responses of High Functional Avidity and Broad Variant Cross-Reactivity Are Associated with HIV Control. PloS one71e29717 pubmed
2011 Preparing for the availability of a partially effective HIV vaccine: some lessons from other licensed vaccines. Vaccine29366072-8 pubmed
2011 CD39/adenosine pathway is involved in AIDS progression. PLoS pathogens77e1002110 pubmed
2011 Genomewide Association Study for Determinants of HIV-1 Acquisition and Viral Set Point in HIV-1 Serodiscordant Couples with Quantified Virus Exposure. PloS one612e28632 pubmed
2011 Definition of the viral targets of protective HIV-1-specific T cell responses. Journal of translational medicine91208 pubmed
